Abstract The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan metabolites and is an immune regulator. However, the role of AhR in SARS-CoV-2 infection and whether AhR can be used as the target of antiviral
Published in: "Science Advances".
Abstract DNA interstrand crosslinks (ICLs) pose a major obstacle for DNA replication and transcription if left unrepaired. The cellular response to ICLs requires the coordination of various DNA repair mechanisms. Homologous recombination (HR) intermediates generated in response to ICLs, require efficient and timely conversion by structure-selective endonucleases. Our knowledge
Published in: "Science Advances".
Abstract In aromatic systems with large π-conjugated structures, armchair and zigzag configurations can affect each material’s electronic properties, determining their performance and generating certain quantum effects. Here, we explore the intrinsic effect of armchair and zigzag pathways on charge transport through single hexabenzocoronene molecules. Theoretical calculations and systematic experimental
Published in: "Science Advances".
Abstract Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease. Here, we report an oral polyphenol-armored nanomedicine based on tumor necrosis factor–α (TNF-α)–small interfering RNA and gallic acid–mediated graphene quantum dot (GAGQD)–encapsulated bovine serum albumin nanoparticle,
Published in: "Science Advances".
Abstract All-inorganic CsPbI 3 perovskite solar cells (PSCs) with efficiencies exceeding 20% are ideal candidates for application in large-scale tandem solar cells. However, there are still two major obstacles hindering their scale-up: (i) the inhomogeneous solid-state synthesis process and (ii) the inferior stability of the photoactive CsPbI 3 black
Published in: "Science Advances".
Abstract Genome-wide phenotypic screens in the budding yeast Saccharomyces cerevisiae , enabled by its knockout collection, have produced the largest, richest, and most systematic phenotypic description of any organism. However, integrative analyses of this rich data source have been virtually impossible because of the lack of a central data
Published in: "Science Advances".
Abstract Calcins are peptides from scorpion venom with the unique ability to cross cell membranes, gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion channels that control release of Ca 2+ from the endoplasmic and sarcoplasmic reticulum. Calcins target RyRs and induce long-lived subconductance states, whereby single-channel
Published in: "Science Advances".
Abstract Unlike conventional laser, the topological laser is able to emit coherent light robustly against disorders and defects because of its nontrivial band topology. As a promising platform for low-power consumption, exciton polariton topological lasers require no population inversion, a unique property that can be attributed to the part-light-part-matter
Published in: "Science Advances".
Abstract Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the underlying molecular mechanisms have not been fully elucidated. Here, by leveraging single-cell RNA sequencing (RNA-seq), assay for transposase-accessible chromatin using sequencing (ATAC-seq),
Published in: "Science Advances".
Abstract Recent studies have described a DNA damage tolerance pathway choice that involves a competition between PrimPol-mediated repriming and fork reversal. Screening different translesion DNA synthesis (TLS) polymerases by the use of tools for their depletion, we identified a unique role of Pol Îą in regulating such a pathway
Published in: "Science Advances".
Abstract Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here, we demonstrate that this abnormality is associated with compromised interleukin-6 (IL-6)–glycoprotein 130 (GP130) signaling
Published in: "Science Advances".
Abstract Deficiencies in mitochondrial protein import are associated with a number of diseases. However, although nonimported mitochondrial proteins are at great risk of aggregation, it remains largely unclear how their accumulation causes cell dysfunction. Here, we show that nonimported citrate synthase is targeted for proteasomal degradation by the ubiquitin
Published in: "Science Advances".
Abstract Energy-efficient, healthy lighting is vital for human beings. Incandescent lighting provides high-fidelity color rendering and ergonomic visual comfort yet is phased out owing to low luminous efficacy (15Â lumens per watt) and poor lifetime (2000 hours). Here, we propose and experimentally realize a photon-recycling incandescent lighting device (PRILD) with
Published in: "Science Advances".
Abstract Metastasis is the main cause of death in many cancers including colorectal cancer (CRC); however, the underlying mechanisms responsible for metastatic progression remain largely unknown. We found that nuclear TYRO3 receptor tyrosine kinase is a strong predictor of poor overall survival in patients with CRC. The metastasis-promoting function
Published in: "Science Advances".
Abstract Photonic time crystals are artificial materials whose electromagnetic properties are uniform in space but periodically vary in time. The synthesis of these materials and experimental observation of their physics remain very challenging because of the stringent requirement for uniform modulation of material properties in volumetric samples. In this
Published in: "Science Advances".
Abstract Interfaces of van der Waals (vdW) materials, such as graphite and hexagonal boron nitride (hBN), exhibit low-friction sliding due to their atomically flat surfaces and weak vdW bonding. We demonstrate that microfabricated gold also slides with low friction on hBN. This enables the arbitrary post-fabrication repositioning of device
Published in: "Science Advances".
Abstract Immune checkpoint inhibitors (ICIs) targeting PD-L1 immunotherapy are state-of-the-art treatments for advanced non–small cell lung cancer (NSCLC). However, the treatment response of certain patients with NSCLC is unsatisfactory because of an unfavorable tumor microenvironment (TME) and poor permeability of antibody-based ICIs. In this study, we aimed to discover
Published in: "Science Advances".
Abstract The mechanisms underlying ETS -driven prostate cancer initiation and progression remain poorly understood due to a lack of model systems that recapitulate this phenotype. We generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein dosage through mutation of its
Published in: "Science Advances".
Abstract Understanding spinterfaces between magnetic metals and organic semiconductors is essential to unlock the great potentials that organic materials host for spintronic applications. Although plenty of efforts have been devoted to studying organic spintronic devices, exploring the role of metal/molecule spinterfaces at two-dimensional limit remains challenging because of excessive
Published in: "Science Advances".
Abstract Intrinsically disordered protein regions are of high importance for biotic and abiotic stress responses in plants. Tracts of identical amino acids accumulate in these regions and can vary in length over generations because of expansions and retractions of short tandem repeats at the genomic level. However, little attention
Published in: "Science Advances".