Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth [Microbiology]

Among CD4+ T cells, T helper 17 (Th17) cells are particularly susceptible to HIV-1 infection and are depleted from mucosal sites, which causes damage to the gut barrier, resulting in a microbial translocation-induced systemic inflammation, a hallmark of disease progression. Furthermore, a proportion of latently infected Th17 cells persist long…

Published in: "PNAS".